8 research outputs found
The Effectiveness of Augmented Reality as a Facilitator of Information Acquisition in Aviation Maintenance Applications
Until recently, in the field of Augmented Reality (AR) little research attention has been paid to the cognitive benefits of this emerging technology. AR, the synthesis of computer images and text in the real world, affords a supplement to normal information acquisition that has yet to be fully explored and exploited. AR achieves a more smooth and seamless interface by complementing human cognitive networks, and aiding information integration through multimodal sensory elaboration (visual, verbal, proprioceptive, and tactile memory) while the user is performing real world tasks. AR also incorporates visuo-spatial ability, which involves the representations of spatial information in memory. The use of this type of information is an extremely powerful form of elaboration. This study examined four learning paradigms: print (printed material) mode, observe (video tape) mode, interact (text annotations activated by mouse interaction) mode, and select (AR) mode. The results of the experiment indicated that the select (AR) mode resulted in better learning and recall when compared to the other three conventional learning modes
Augmented Reality as a Training Medium for Aviation/Aerospace Application
Augmented Reality (AR) has the potential to transform aviation/aerospace training by creating new mixed reality worlds that serve as a medium for gaining work related skills. --from the publicatio
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Glucocorticoid receptor recruits to enhancers and drives activation by motif-directed binding
Glucocorticoids are potent steroid hormones that regulate immunity and metabolism by activating the transcription factor (TF) activity of glucocorticoid receptor (GR). Previous models have proposed that DNA binding motifs and sites of chromatin accessibility predetermine GR binding and activity. However, there are vast excesses of both features relative to the number of GR binding sites. Thus, these features alone are unlikely to account for the specificity of GR binding and activity. To identify genomic and epigenetic contributions to GR binding specificity and the downstream changes resultant from GR binding, we performed hundreds of genome-wide measurements of TF binding, epigenetic state, and gene expression across a 12-h time course of glucocorticoid exposure. We found that glucocorticoid treatment induces GR to bind to nearly all pre-established enhancers within minutes. However, GR binds to only a small fraction of the set of accessible sites that lack enhancer marks. Once GR is bound to enhancers, a combination of enhancer motif composition and interactions between enhancers then determines the strength and persistence of GR binding, which consequently correlates with dramatic shifts in enhancer activation. Over the course of several hours, highly coordinated changes in TF binding and histone modification occupancy occur specifically within enhancers, and these changes correlate with changes in the expression of nearby genes. Following GR binding, changes in the binding of other TFs precede changes in chromatin accessibility, suggesting that other TFs are also sensitive to genomic features beyond that of accessibility